Breadcrumb Home > Dictionary > Index C comedo: Meaning and Definition of Find definitions for: com•e•do Pronunciation: (kom'i-dō"), [key] — pl. com•e•dos, com•e•do•nes a thickened secretion plugging a duct of the skin, esp. of a sebaceous gland; blackhead. Random House Unabridged Dictionary, Copyright © 1997, by Random House, Inc., on Infoplease. See also: comedo (Thesaurus) comedist comedown TrendingHere are the facts and trivia that people are buzzing about. Hanukkah Origins of the Christmas Holiday Jewish Holidays, 2010-2030 (A.M. 5770-5791) Western Christian Holidays, 2010-2030 Krampus: The Christmas Devil Kwanzaa ✖ Related Content Daily Word Quiz: anomie Analogy of the Day: Today’s Analogy Frequently Misspelled Words Frequently Mispronounced Words Easily Confused Words Writing & Language